Bioinformatic tools &
Yeast CRISPR CUREs
Bioinformatic Tools :
BUDDY Bioinformatic Utility for Diagnostic Discovery in Yeast.
Bioinformatic pipeline to model human variants of unknown significance in yeast and test with functional assays.
CODY CRISPR Oligo Design in Yeast
sgRNA cloning and repair template generator for introducing missense mutations in the yeast genome using CRISPR/Cas9 (designed for use with pML104 type plasmids).
DROGA Drug Response of Genetic Alleles
Pipeline to identify human variants within or near drug-binding pockets and assesses their pharmacogenomic impact through CRISPR-based yeast drug resistance assays.
ALINEy Aminoacid Lookup Interface for Nonsynomous Entries in Yeasts
ALINEy aligns and maps manual mutations between human and yeast for visualization.
noVUS Novel Ortholog Validation Using Saccharomyces
Software for clinicians to submit VUS mutations for yeast experiential analysis.
Yeast Doubling Time (DT) calculator
Calculates doubling times from 96well liquid culture assays.
Yeast Chronological Lifespan (CLS) Analysis
Software to analyze yeast CLS assays.
Biochem CURE Protocols:
Published protocols coming soon